Xu M*, Zhong XZ*, Huang P*, Jaślan D*, Wang P, Sun X, Weiden EM, El Hiani Y, Grimm C, Dong XP. TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P. (*equal contribution), PNAS. 2023;120(34):e2215777120.
Huang P, Cao Q, Xu M, Dong XP. Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D. Cells. 2022 Mar 4;11(5):887.
Sun X, Xu M, Cao Q, Huang P, Zhu X, Dong XP. A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release. Sci Rep. 2020;10(1):1038.
Yang Y, Xu M, Zhu X, Yao J, Shen B, Dong XP. Lysosomal Ca2+ release channel TRPML1 regulates lysosome size by promoting mTORC1 activity. Eur J Cell Biol. 2019;98(2-4):116-123.
Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP. The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Cell Calcium. 2019;79:80-88.
Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. A negative feedback regulation of mTORC1 activity by the lysosomal Ca2+ channel TRPML1 using a calmodulin-dependent mechanism. Autophagy, 2018; 14(1):38-52.
Cao Q, Yang Y, Zhong XZ, Dong XP. The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin. J Biol Chem. 2017; 292(20):8424-8435.
Huang P, Li W, Yang Z, Zhang N, Xu Y, Bao J, Jiang D, Dong X. LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization. PLoS One. 2017; 12(2):e0171452.
Zhong XZ, Zou Y, Sun X, Dong G, Cao Q, Pandey A, Rainey JK, Zhu X, Dong XP. Inhibition of TRPML1 by lysosomal adenosine involved in severe combined immunodeficiency diseases. J Biol Chem. 2017; 292(8):3445-3455.
Zhong XZ, Sun X, Cao Q, Dong G, Schiffmann R, Dong XP. BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases. Sci Rep. 2016; 6:33684.
Zhong XZ, Cao Q, Sun X, Dong XP. Activation of lysosomal P2X4 by ATP transported into lysosomes via SLC17A9 using V-ATPase generated voltage gradient as the driving force. J Physiol. 2016; 594(15):4253-66.
Cao Q, Zhong XZ, Zou Y, Murrell-Lagnado R, Zhu MX, and Dong XP. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol. 2015; 209(6):879-94. Highlighted in the 'In This Issue' section.
Cao Q*, Zhong XZ *, Zou Y, Zhang Z, Ligia T, Dong XP. BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release. Dev Cell. 2015; 33(4):427-41. (*equal contribution). Evaluated by Faculty of 1000: F1000Prime.com/725503622.
Cao Q, Zhao K, Zhong XZ, Zou Y, Yu H, Huang P, Xu TL, Dong XP. SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability. J Biol Chem. 2014; 289(33):23189-99.
Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, Murrell-Lagnado R, Dong XP. P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH. J Biol Chem. 2014; 289(25):17658-67.
Dong XP*, Shen D*, Wang X*, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman L, Delling M, and Xu H. PI(3,5)P2 controls intracellular membrane traffic by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nature Commun. 2010, 1: 38 (*equal contribution).
Dong XP*, Wang X*, Shen D*, Chen S, Liu M, Wand Y, Mills E, Cheng X, Delling M, Xu H. Activating mutations of the TRPML1 channel revealed by proline scanning mutagenesis. J Biol Chem. 2009, 284: 32040-52 (*equal contribution).
Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008, 455: 992-997.
Li XM*, Dong XP*, Luo SW, Zhang B, Lee DH, Ting AK, Neiswender H, Kim CH, Carpenter-Hyland E, Gao TM, Xiong WC, Mei L. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nat Neurosci. 2008, 11: 262-268 (*equal contribution).
Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L. Shp2 is dispensable in the formation and maintenance of the Neuromuscular Junction. Neurosignals. 2006, 15: 53-63.
Dong XP, Xu TL. The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth & Analg. 2002, 5: 907-914.
Dong XP, Xu TL. Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons. Brain Res. 2002, 940: 1-9.
Huang P, Dong RY, Wang P, Xu M, Sun X, Dong XP. MCOLN/TRPML channels in the regulation of MTORC1 and autophagy. Autophagy. 2024 Jan 5:1-2
Peng F, Wu Y, Dong X, Huang P. Proton-Activated Chloride Channel: Physiology and Disease, Front Biosci. 2023 Jan 16;28(1):11.
Huang P, Xu M, Wu Y, Rizvi Syeda AK, Dong XP. Lysosomal potassium channels. Endolysosomal voltage-dependent cation channels (edited by Dr. Christian Wahl-Schott and Dr. Martin Biel at the University of Munich). Handb Exp Pharmacol. Springer, 2022 (Book chapter).
Wu Y, Xu M, Wang P, Syeda AKR, Huang P, Dong XP. Lysosomal potassium channels. Cell Calcium. 2022; 102:102536.
Wu Y, Huang P and Dong XP. Lysosomal calcium in autophagy and cancer. Cancers (Basel). 2021; 13(6):1299.
Xu M, Dong XP. Endolysosomal TRPMLs in Cancer. Biomolecules. 2021; 11(1):65.
Huang P, Xu M, Wu Y, Dong XP. Lysosomal ion channels and human diseases. Nonclassical Ion Channels in the Nervous System (edited by Dr. Tianle Xu at Shanghai Jiao Tong University and Dr. Longjun Wu at Mayo Clinic). Taylor & Francis Group CRC Press/Chapman & Hall, 2021 (Book chapter).
Huang P, Xu M, Wu Y, Rizvi Syeda AK, Dong XP. Multiple facets of TRPML1 in autophagy. Cell Calcium. 2020; 88:102196 (Review).
El Hiani Y, Egom EE, Dong XP. mTOR signalling: jack-of-all-trades. Biochem Cell Biol. 2019;97(1):58-67 (Review).
Zhong XZ, Yang Y, Sun X, Dong XP. Methods for monitoring Ca2+ and ion channels in the lysosome. Cell Calcium. 2017; 64:20-28 (Review).
Zhong XZ, Dong XP. Lysosomal Electrophysiology. Methods Cell Biol - Lysosomes and Lysosomal Diseases (edited by Dr. Frances Platt and Dr. Nick Platt at the University of Oxford), 2015, 126: 197-215. Elsevier (Book Chapter).
Dong XP, Wang X, Xu H. TRP channels in the intracellular membranes. J Neurochem. 2010, 113: 313-28 (Review).
Mills E, Dong XP, Wang F, Xu H. Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders. Future Medicinal Chemistry. 2010, 2: 51-64 (Review).
Dong XP, Zhi G, Xu TL. Calmodulin modulation of ion channels and receptors. Prog Nat Sci. 2002, 12:241-248 (Review).
Capurro MI, Greenfield LK, Prashar A, Xia S, Abdullah M, Wong H, Zhong XZ, Bertaux-Skeirik N, Chakrabarti J, Siddiqui I, O'Brien C, Dong X, Robinson L, Peek RM Jr, Philpott DJ, Zavros Y, Helmrath M, Jones NL. VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1. Nat Microbiol. 2019;4(8):1411-1423.
Huang P, Shi J, Sun Q, Dong X, Zhang N. Engineering Pichia pastoris for Efficient Production of a Novel Bifunctional Strongylocentrotus purpuratus Invertebrate-Type Lysozyme. Appl Biochem Biotechnol. 2018;186(2):459-475.
Chen JY, He XX, Ma C, Wu XM, Wan XL, Xing ZK, Pei QQ, Dong XP, Liu DX, Xiong WC, Zhu XJ. Netrin-1 promotes glioma growth by activating NF-κB via UNC5A. Sci Rep. 2017; 7(1):5454
Wang YZ, Zeng WZ, Xiao X, Huang Y, Song XL, Yu Z, Tang D, Dong XP, Zhu MX, Xu TL. Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death Differ. 2013; 20(10):1359-69.
Wang X*, Zhang X*, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012, 372-383 (*equal contribution).
Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD, Xu H. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nature Commun. 2012, 3:731.
Cheng X*, Jin J*, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010, 141: 1-13 (*equal contribution).
Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. PNAS. 2007, 104: 18321-18326.
Luo S, Zhang B, Dong XP, Tao Y, Ting A, Zhou Z, Meixiong J, Luo J, Chiu FCA, Xiong WC, and Mei L. HSP90β regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron. 2008, 60: 97-110.
Woo RS, Li XM, Tao Y, Carpenter-Hyland E, Huang YZ, Weber J, Neiswender H, Dong XP, Wu J, Gassmann M, Lai C, Xiong WC, Gao TM, Mei L. Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 2007, 54: 599-610.
Zhang B*, Luo S*, Dong XP*, Zhang X, Liu C, Luo Z, Xiong WC, Mei L. β-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J Neurosci. 2007, 27: 3968-73 (*equal contribution).
Zhang ZX, Lu H, Dong XP, Liu J, Xu TL. Kinetics of etomidate actions on GABA(A) receptors in the rat spinal dorsal horn neurons. Brain Res. 2002, 953: 93-100.
Xu TL, Dong XP, Wang DS. N-methyl-D-aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons. Eur J Neurosci. 2000, 12: 1647-1653.
